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Estrogen can inhibit the metabolism of cyclosporine resulting in increase of its levels in blood and kidney and/or liver damage. Estrogen may increase the risk of liver disease in patients treated by dantrolene. Known to affect a clot formation Estrace should be used carefully together with warfarin (Coumadin). Enhanced metabolism and excretion of Estrace may be stipulated by rifampin, barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin) and primidone.
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