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The duration of anticoagulant therapy following tissue heart valve replacement surgery is usually 6 to 12 weeks. The duration of therapy may be longer in patients with a tissue valve in the mitral location, particularly in the presence of a large left atrium and/or atrial fibrillation. In patients who receive a mechanical heart valve, lifelong anticoagulant therapy is usually needed and low dose aspirin (80 to 100 mg/day) may be added in higher risk patients.
The duration of anticoagulant therapy for a first-time deep venous thrombosis is usually 3 to 12 months, depending on the reversibility of the condition which may have predisposed this patient to thrombosis. For patients with a first episode of DVT secondary to a reversible risk factor, 3 months of warfarin therapy is recommended. For patients with a first episode of idiopathic DVT, at least 6 to 12 months of treatment is recommended. For patients with two or more episodes of documented DVT, indefinite treatment with warfarin is recommended. For patients with a first episode of DVT who have documented antiphospholipid antibodies or who have two or more thrombophilic conditions, treatment for 12 months is recommended and indefinite therapy is suggested. For patients with a first episode of DVT who have documented deficiency of Protein C or Protein S, deficiency of antithrombin, or the Factor V Leiden or prothrombin 20210 gene mutation, homocystinemia, or high Factor VIII levels, treatment for 6 to 12 months is recommended and indefinite therapy is suggested for idiopathic thrombosis.
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The duration of anticoagulant therapy for a first-time deep venous thrombosis is usually 3 to 12 months, depending on the reversibility of the condition which may have predisposed this patient to thrombosis. For patients with a first episode of DVT secondary to a reversible risk factor, 3 months of warfarin therapy is recommended. For patients with a first episode of idiopathic DVT, at least 6 to 12 months of treatment is recommended. For patients with two or more episodes of documented DVT, indefinite treatment with warfarin is recommended. For patients with a first episode of DVT who have documented antiphospholipid antibodies or who have two or more thrombophilic conditions, treatment for 12 months is recommended and indefinite therapy is suggested. For patients with a first episode of DVT who have documented deficiency of Protein C or Protein S, deficiency of antithrombin, or the Factor V Leiden or prothrombin 20210 gene mutation, homocystinemia, or high Factor VIII levels, treatment for 6 to 12 months is recommended and indefinite therapy is suggested for idiopathic thrombosis.
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